Highly enantioselective reduction of ketones using Corey–Itsuno reduction using CBS catalyst.
04.10.2021 16:29
Asymmetric synthesis configuration of chiral R-OH or S-OH using Corey–Itsuno reduction using CBS catalyst.
Is a matter of choice in nearly quantitative yield !
(S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole
(S) Corey–Bakshi–Shibata (CBS) reducing agent
Corey–Itsuno reduction, known as the Corey–Bakshi–Shibata (CBS) reduction, is a chemical reaction in which ketone is enantioselectively reduced to produce the chiral, non racemic alcohol. S- Oxazaborolidine reagent which mediate enatioselective reduction of ketones to chiral R- alcohol in quantitative yield.
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DOI: doi.org/10.1021/acs.joc.0c01764
