DISCLAIMER :
This section only summarizes the theoretical path of synthesis (without details/detailed instructions of the requirment for a successful reaction run. Experimental detailed details are omitted due to safety concern and legal reasons ) of some certain compounds which are subject to research and development and educational purpose only for individuals and government authoritys. Lets make any field knowladgebase available to all. (Hidding any knowladge in any field from others may strongly be related to paranoid delusional disorder of individual ( for which he already realise that its stands on fragile foundations ) again and again related to mAChRs issues with consequently cognitive decline. ) Any unskilled attempt ( from a safe or technological point of view ) to synthesize any compounds in this theoretical compound thread without prior calculation and consideration of the reaction conditions or safety precautions can lead to explosion, fire, death , permanent or temporary CNS damage , paralysis or other physical damage to themselves and others in the surroundings area, and most of them are hazardous to the environment.
Just a thought? Aha! So you want to introduce mandatory military service without priorly balancing the muscarinic receptors in males and females. Be prepared for the consequences with a delayed effect. You will cause irreversible damage, because the cholinergic (muscarinic especially at M1 receptor) of the 21st century population is in chaos due to hormonal (Testosterone decline) imbalance. Its way different unbalanced as in population 50-100 years ago. Good luck.
#ECS in Slovenia soon.
#implement ECS therapy in Slovenia under anasthesia for most radicalised right and left wingers which is results from undelined
mental helath condition including for individuals who seek for attention , manipulators, spreading hate and instability via social networks e.g. X etc....and others drug addictiors etc.... Then introduce mandatory military service for them again....BUT NOT PRIORLY BEFORE YOU HAVENT BALANCE CHOLINERGIC SYSTEM as YOU WILL DO A MESS.... The most selective treatments to balance your cholinergic system muscarinic receptor comparable to other traditional drugs. Each person who shows just a slight abuse potentional to consume drugs e.g. MDMA , Cocaine , LSD, Alcohol (even if 1 Liter per year)...Suchlike person should be treated with ECS therapy without any doubts. Suchlike person is dangerous for society (more dangerous than local mass murder shooter) consequently his cholinergic system is a mess.
Effect of electroconvulsive shock on central cholinergic (muscarinic) receptors https://pubmed.ncbi.nlm.nih.gov/7104697/
Additionally you can also :
#Nuke ALL South America cocaine plants with Iranian nukes or use just proper isotope of Uranium or Polonium Dirty Bombs bonded with with secondary explosives e.g. ETN or PETN (the most cheap) on selective Cocaine plants. Put it on Drone and drop it off detonate it with booster det or use (org.phos. Herbicides but efficency may varry) Deport South America population to Greenland and Africa and EU for GENE boost MIX effect as well for better Human EVOLUTION. It may be excellent human evolution effect in decades...PROPER balanced Cholinergic system the most OPTIMAL outcome.
#GOV Militrary takes control over Chemical Industry in EU.
#Problem related to drugs solved 4 EVER.
#Ali Khamenei 4 LIFE (WARNING for WEST : Did you know that more than you will attack IRAN bigger grave you dig yourself...As some kilos of Uranium isotopes or even Po will end on EU blackmarket smuggled VIA road route if not done already...and tommorow EU can be in danger of terroristic attack with Radio. Dirty bombs and some aerosolised inhaled dust of radio. materials after detonation of PETN in individulas presents in close area. (great for reproduction or if inhaled by pregnant female lol) Then you can lockup up some areas of EU for some time. You want that ? Keep it up ;) Enjoy and Pay high cost for Revange.
#Rather Normalize economic relations with IRAN.
#IRAN SANCTION EMBARGO WILL BE OVER SOON.
Some link to interested References:
‘Electroshock Therapy’ in the Third Reich | Medical History | Cambridge Core
Regarded historical research on the Third Reich and the ‘euthanasia’ murders as Henry Friedlander’s The Origins of Nazi Genocide: From Euthanasia to the Final Solution claims that during the Nazi period, electroshock was no therapy, but rather a treatment used to ‘inflict torture’ to some political opponents and others. Third Reich, electroshock therapy was not only introduced in psychiatric hospitals, asylums, and in the Auschwitz concentration camp in order to get patients back to work, it was also modified for ‘euthanasia’ murder. Any clue which party in Slovenia would find himself THE MOST close in this story ? # KARMA
Effect of electroconvulsive shock on central cholinergic (muscarinic) receptors
https://pubmed.ncbi.nlm.nih.gov/7104697/
Intermediates required : Alpha Truxillic acid , DPPA(for diamine) , Safranal
Possible biological activity : Anticancer, Antiviral, Analgesic , Anti-oxidant , butyrylcholinesterase inhibitors & acetylcholinesterase inhibitor (treatment of Alzheimer disease) , selective mAChR antagonist @ M1-M3-M4 receptor.
Disuccinimidyl carbonate (DSC) coupling reagent and practical use case vs. CDI for comparasion.
USE CASE random pick up design
Synthesis of
Rivastigmine EP Impurity B
intermediates needed :
Pyridine-2-carbaldehyde + Ethyl (triphenylphosphanylidene)acetate = Ethyl (E)-3-(2-pyridyl)acrylate + hydrolysis esters = (E)-3-(2-Pyridyl)acrylic acid + SOLARIUM SUNBED (280-365nm) = (1R,2R,3S,4S)-2,4-Bis(2-pyridyl)-1,3-cyclobutanedicarboxylic acid + hydroxylamine HCl + base for OXIME + CH3Cl for quaternary ammonium chloride salts.
