M1 M2 M3 M4 M5 selective with moderate receptor affinity

Imine  Intermediate for previous topic - Borneophos -

Convert carboxylic acid to amine in one-pot or directly to alpha substituted aryl-alkyl- ketone.

In presence of various boronic acids and various aryl halide

WARNING: Diphenylphosphoryl azide (DPPA) is highly toxic compound  its properties as organophosphorus azide (it means it easily penetrates skin and cause delayed systemic poisoninng affect CNS or cause even death due to respiratory failure. Dual mild AChEIs & BuChE inhibitor ) its comparable with toxicity of organophosphorus nerve agents. Highly toxic in contact with skin and if inhaled.