Bargellini rxn. direct synthesis of carboxylic acid. Preferable way of synthesis (R 'COOH).
Versatile Non-Nitrile route.
T-BOC aziridine derivates from chiral aminoalcohols can be employeed as interesting intermediate in preparation of T-BOC chiral alkyl- aryl- amides
THANKS TO VICTOR GRIGNARD
6 May 1871 – 13 December 1935
Forget about chiral resolving agents.
LIGAND FOR HIYAMA COUPLING REACTIONS
Esterification of Carboxylic Acids by various coupling reagents (CDI, PYBOP, DCC , EDC) in moderate high yield.
1.) oxidation of primary alcohol to carboxylic acid
2.) Acylation of nitrogen nucleophiles by carboxylic acids