FINALLY NOW USED "CHEMDOODLE 2D" LICENSED appZ DUE TO LEGAL AND ETHETIC REASONS. IN FUTURE BLOG  WILL BE USED CHEMDODDLE SOFTWARE TO DRAW MOLECULAR STRUTURE. WILL BE SLIGHTLY DIFFERENT THEMPLATE AS PREVIOUSLY MOLECULAR STRUCTURE DESIGN. ADVANTAGE : MORE BOLD TRANSPARENTLY ENRICHED MOL STRUCTURE DESIGN and LICENSED. ¯\_(ツ)_/¯ 

One random design of potent Norepinephrine–dopamine reuptake inhibitor (NDRI) and partial antagonist of mAChRs (M1-M5) . Please note all drugs which works besides of NDRI or any other receptor along with muscarinic antagonist activity are usually "red flagged drugs" which provide high abuse liability and provide compulsive reinforcing effect to certain drug. You can also predict that suchlike drugs has high potentionals to cause delirium state if abused due to mAChR antagonistic effect. So you can easily predict properties which compound has abuse liabilty drugs besides of MRAs (muscarinic antagonists) + NDRI combo which have usually in some cases  synergetic effect.

3-{7-benzyl-7-azaspiro[3.5]nonan-2-yl}-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propan-1-one

SMILES : O=C(CCC1CC2(C1)CCN(CC1=CC=CC=C1)CC2)C1=CC2=C(OCCO2)C=C1

3-{7-benzyl-7-azaspiro[3.5]nonan-2-yl}-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-fluoropropan-1-one 

SMILES: FC(CC(=O)C1=CC2=C(OCCO2)C=C1)C1CC2(C1)CCN(CC1=CC=CC=C1)CC2

Relative potent Acetylcholinesterase + Butyrylcholinesterase inhibitor and some novel analog of Donepezil as potentional cognitive enhacer drug for treating Alzerheimer dissase individuals as well as healthyl individual. How do you know at all as healthy individual that you are truly cognitively healthy ?  Did you know that even Testosterone has been shown to be unique regulator and inhibitor of Acetylcholinesterase + Butyrylcholinesterase therefore most of population is suffering in decline of Testosterone and consequently decline of cognitive performances. When you will start to realize that we are living in epidemic of hypogonadism in both gender ? Simple equation Low Testosterone = Borderline nearly invisible delirium without being realized it. Antagonised mAChRs or dysregulation. And consequently partialy blocked acetylcholine in synapse which results in cognitive decline with time.

USED WITH LICENSED CHEMBUDDY appZ.

2-fluoro-5-methyl-4-nitrophenyl bis(propan-2-yl) phosphate

O-2-fluoro-5-methyl-4-nitrophenyl O,O-bis(propan-2-yl) phosphorothioate

(2-fluoro-5-methyl-4-nitrophenoxy)bis(propan-2-yloxy)-λ⁵-phosphaneselone​

[2-(ethylsulfanyl)ethoxy][(propan-2-yl)amino]phosphinoyl fluoride

Short aspect in field of OPCs and Carbamates (next time) which are potent AChE , BChE inhibitors (Acetylcholinesterase + Butyrylcholinesterase inhibitor) which could be used as aid in discovering and treating several neurological disorder e.g. POTS , Alzerheimer dissase , cognitive decline etc...Slight inhibition of AChE may improve your memory processes and cognitive performance. Besides of its extreme toxicity especially via dermal , inhalation , SUB , IM , IV exposure.  Please note for some certain ChEls even in microdosage is typically known that therapeutic and lethal dose are like tiny close to each other. Its good to mention that high testosterone levels also modulate cholinesterase activity making the brain less relliant on external factors cholinesterase inhibitors e.g. OPCs to maintain acetylcholine levels. This could mean that a person with higher testosterone might better maintain cholinergic function. It also protect mitochondrial function. So if you would put two volunters exposed to certain OPCs the 1st who has low Testosterone and other one has high Testosterone. The first one will likely feel any symptoms in much lower concentration than 2nd volunter with high Testosterone. But this does not mean that volunter with high testosterone are now resistant to OPCs. NO! Probably they are protected for 25% more pers dose @ LD50 more than person with low Testosterone.  Dont forget Testosterone is neuroprotectant for whole CNS.  Its same with other stimulation drugs person who has low testosterone will feel each and any effect of certain drugs even on alcohol on high screen than person with High Testosterone he will rarely feel any effect on certain drugs why ? Due to mAChRs regulation. More antagonized mAChRs (Muscarinic acetylcholine receptors) more effect you will feel on certain drugs.  Its same with reinforcing effect (craving) volunter with high Testosterone will less likely have reinforcing effect to some ceratin drugs than volunter with low Testosterone. We should esstablish HQ society worldwide : Société de testostérone élevée. Even alcohol abuse is lowering reduce your Testosterone and elevate your Estrogen levels. Estrogen should be treated as neurotoxin in case  if in inapropiate ratio with Testosterone. Elevated estrogen levels more antagonised  mAChRs (welcome to borderline delirium) as well as minimised mitochondiral function. I dont remember yet where I have seen pink flags floating around. Delirium is always Colorful.

You are kindly advised prior any synthesis or research involvment with OPCs or Carbamates that you measure your Serum cholinesterase for 1month (ChE) at blood work ( 5,50 EUR @ ADRIALAB Slovenia ) and you get your default approx. level values of ChE priorly any involvement with OPCs or Carbamates highly recommended ) then you see with timeline how much ChE were adjusted when you have involved with OPCs or Carbamates espesially useful in sense of chronic exposure with OPCs in minimal quantites so you know when its time to minimise exposure for some time. You have compass not just symptoms onset when to late and when you fall into cholinergic crisis.  Therefore before any involvement with OPCs or Carbamates besides of safety precatution e.g. use ducted fumehood , butyl rubber gloves or double layered nitrile gloves , MIRA Safety CM-6M , with double NBC-17 SOF filter. You can additionaly addtionaly protect yourself and inject yourself via Intramuscular (IM) injection with mixed testosterone esters "SUSTANON or single ester" If you are research male dosage yourself with SUSTANON 250mg/ml (for some males e.g. 1.5ml=375mg OK find your own dose yourself) if you are research female 30mg use approx (for some females e.g. 0.15ml= 37.5mg OK find your own dose yourself) 1day before involvement make sure you limit alcohol or caffeine ingestion at least 2week before. Avoid any alcohol or caffeine , other drugs intake at least 2 weeks before any involvement with OPCs. (for your good cut it off permanently ) Good to know at meanwhile : You drink and you like caffeinated drinks because you are borderline Anemic because of Hepcidin protein issues. ; due to your Low Testosterone. Elevated Testosterone which inhibit/Lower Hepcidin protein levels which favor bone marow iron supply for hemoglobin synthesis and red blood cells production ) 

Synthesis of  1-(4-fluorophenyl)-2, 2-dimethyl-3-azabicyclo[3.1.0]hexane   [ & ]  N,2'-dimethyl-1'-phenyl-[1,1'-bi(cyclopropane)]-1-amine