intermediates needed :
Pyridine-2-carbaldehyde + Ethyl (triphenylphosphanylidene)acetate = Ethyl (E)-3-(2-pyridyl)acrylate + hydrolysis esters = (E)-3-(2-Pyridyl)acrylic acid + SOLARIUM SUNBED (280-365nm) = (1R,2R,3S,4S)-2,4-Bis(2-pyridyl)-1,3-cyclobutanedicarboxylic acid + hydroxylamine HCl + base for OXIME + CH3Cl for quaternary ammonium chloride salts.
Nearly 100% natural compound :
Intermediates required : Alpha-Truxillic acid , (Choline Chloride + ZnCl2 )(DES) , Solvents or coupling reagents : CDI , DCC , pyBOP...
GREEN Synthesis Directly from R'COOH (no halogenation required priorly) w/ :
1. Deep Eutectic Solvents (DES)
or
2. Coupling Reaction (EDC.HCl or CDI pyBOP...)