Bargellini rxn. direct synthesis of carboxylic acid. Preferable way of synthesis (R 'COOH).

Versatile Non-Nitrile route.

T-BOC aziridine derivates from chiral aminoalcohols can be employeed as interesting intermediate  in preparation of T-BOC chiral alkyl- aryl- amides

THANKS TO VICTOR GRIGNARD 

6 May 1871 – 13 December 1935

 

Forget about chiral resolving agents.

Esterification of Carboxylic Acids by various coupling reagents (CDI, PYBOP, DCC , EDC) in moderate high yield.

1.) oxidation of primary alcohol to carboxylic acid

2.) Acylation of nitrogen nucleophiles by carboxylic acids

 

Isomerlab d.o.o.

 Naslov: Tržaška cesta 297 A , SI-1000 Ljubljana , Slovenia

 Phone: +386 40 764 332

 Email: info@isomerlab.com

Cookie - Analitics
They are used to record the website's obscurity analysis and provide us with data to provide a better user experience.
Cookie - social
Cookies required for plug-ins for sharing content from social media sites.
Cookie - chat
Cookies allow you to sign up, contact and communicate through the communication plug-in on the page.
Cookie - marketing
They target targeted advertising based on past user's activity on other sites.
What are cookies?
By visiting and using the site, you consent to the use and recording of cookies.OK Learn more about cookies