DISCLAIMER :
This section only summarizes the theoretical path of synthesis (without details/detailed instructions of the requirment for a successful reaction run. Experimental detailed details are omitted due to safety concern and legal reasons ) of some certain compounds which are subject to research and development and educational purpose only for individuals and government authoritys. Lets make any field knowladgebase available to all. (Hidding any knowladge in any field from others may strongly be related to paranoid delusional disorder of individual ( for which he already realise that its stands on fragile foundations ) again and again related to mAChRs issues with consequently cognitive decline. ) Any unskilled attempt ( from a safe or technological point of view ) to synthesize any compounds in this theoretical compound thread without prior calculation and consideration of the reaction conditions or safety precautions can lead to explosion, fire, death , permanent or temporary CNS damage , paralysis or other physical damage to themselves and others in the surroundings area, and most of them are hazardous to the environment.
23.04.2025 12:14
w/ more greener route ; coupling reaction using :
TCDI reagent
TBDMSCl (for alcohol protection)(optional)
3-(dimethylamino)benzene-1-thiol = (3-Aminophenol + formaldehyde + STAB or Formic acid Eschweiler–Clarke reaction or Me2SO4) + (Lawesson reagent for 3-(dimethylamino)benzene-1-thiol)
Dimethylamine HCl or freebase 2M in THF
triethylamine(base)
CH3I or CH3Br or CH3Cl
Sodium tetrafluoroborate
19.04.2025 15:49
GREEN Directly from R'COOH w/ :
1. Deep Eutectic Solvents (DES)
or
2. Coupling Reaction (EDC.HCl or CDI pyBOP...)
