Modified Steglich esterification of (2R)-4-Anilino-1-tert-butoxycarbonyl-2-methyl-4-piperidinecarboxylic acid without using alkylating agents e.g. Iodomethane. With first Steglich looks a bit comlicated with extra problems comparable with clasic alkylation with iodomethane, dimethyl sulfate etc....but once you optimise it you forget about classic alkylations.

Incl. 3 methods . Detection with TLC and GC charts & Yield optimisation of using EDC HCl and HBTU reagent and compariation. 

In same manner can be done on various amino acids e.g. Ritalinic acid ....or on other application e.g. esterification of di/mono  alkylphosphonic acids

-Everyone could do everything to contribute  like in old WAREZ  closed group FXP-ing scene everyone should have certain work/ like in closed FXP scene ...remember  yet years 2000 ? Missed experience ? missed gold experience pattern.  

1. group IP PORT SCANNERz proxyZ, 2. group HackerZ sql injection , 3. group afill. dump fillerZ FXP-ing to dumps from topsites 100mbit with 0sec PRE release stuff 100/100mbit  -=APPZ=- , -=GAMEZ=- , -=MP3=- , -=MOVIEZ=- , -=DOX=-  of 1TB of data to dumps 10mbit/20mbit/50mbit    ;

4.group dumps to dumps private....5.group dumps to public ftpZ. (used by lowest level --bone lining-- known as l33cherZ ..n00bz)

e.g. DEVIANCE TOPSITES 100MBIT /100mbit ; e.g. FAR CRY 1 linked news to IRC bot channels  from FTP topsites **NEW RELEASE** 0SEC AFTER PRE RELEASE  SECTION [GAMEZ][FAR CRY 1]   STILL REMEMBER ?

On same matter we could do in chemistry field. But in Chemistry OCSLAB would be open portal  with some private section and everyone  in team would have certain work.   Or make it in different rolle commercial BUY IT NOW and offer live reaction research  progress of certain compound rather than making commerical compounds building block products. Instead of that rather to make LIVE progress of reaction synthesis some kind of upgrade version of REAXYS or CAS SCIFINDER UPGRADE ...but we need  large team like in old wareZ scene. Interested in cooperation ?  Contact. Lets make peoples addicted to science (how things works in praxis)rather than drugs.

this is one plain beta example 1 of 1mio compounds.

-Historical recurrence

Too saturated/overloaded with phenyl groups ? and excesivelly too bulky structure out of geometrical structure range ? But it seems promising. Stereoisomerism may vary after modification of Truxillic acids especially for 1st and 3rd example to unknown stereoisomers  ​...

-Synthesis  your own dibenzo[b,f][1,4]oxazepine up to w/v 1% solution of combo hybride and PLAY.

Besides of extreme lachrymator potency can be widely used as anti-inflammatory agent for various application. To reverse effect of lachrymation you may want to inject I.M or I.V  - TRPA1 antagonist to reverse its effects of lachyrmation and burning sensation rapidly. Perhaps may work with HC-030031 agent (IC50s of 6.2±0.2 and 5.3±0.2 μM​) ? or proposed design structure in SMILES : O=C(N(CCC1(CN2)N(C2=O)C(=CC=C2)C=C2)[C@H](C1)C)[C@@H]([C@@H]1C(=CC=C2)C=C2)[C@H]([C@@H]1C(=O)OC(C)C)C(C=CC1)=CC=1 or O=C(OC(C)C)C([C@@H]1C(C=CC2)=CC=2)[C@H](C1CCN(CCC1(CN2)N(C2=O)C(C=CC2)=CC=2)[C@H](C1)C)C(C=CC1)=CC=1

Synthesis of : UPSILON-TRUXILLIC ACID , EPSILON-TRUXILLIC ACID , BETA-TRUXINIC ACID , DELTA-TRUXINIC ACID , ALPHA-TRUXILLIC ACID , EPI-TRUXILLIC ACID , PERI-TRUXILLIC ACID , MU-TRUXINIC ACID