IN VITRO : Novel potent apoptosis inducer in Glioblastoma multiforme (GBM; grade IV astrocytoma) cancer stem cells (CSCs), inducing caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex

tert-butyl 4-hydroxy-4-phenylpiperidine-1-carboxylate , CAS: 172734-33-7

Weinreb amide

1-Boc-4-phenylamino-piperidine , CAS: 125541-22-2

Phosphoryl bromide , CAS: 7789-59-5

Carboxylic acid to Alkane reducing agent

2-bromo-2-(2-ethyl)dioxolane , CAS: 18742-02-4

Boc anhydride , Boc2O , Di-tert-butyl dicarbonate , CAS: 24424-99-5 BOC Protection of amines

IN VITRO : RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM

Phase-transfer catalyst - PTC

1-(1,3-Benzodioxol-5-yl)-1-butanone , CAS: 63740-97-6

4-methyl-1-(3-[(4-methylpiperidin-1-yl)methyl]-2,4-diphenylcyclobutylmethyl)piperidine , CAS: N/A

1-(2H-1,3-benzodioxol-5-yl)-3-ethylpentan-1-one

CAS: 602-85-7 , 9,10-Didehydro-6-methylergoline-8β-methanol , Lysergol

3,4-(methylenedioxy)benzoic acid ; Piperonylic acid ; CAS: 94-53-1